O 38.six in group two (p = 0.64). Median APACHE II scores have been ve…

O 38.6 in group 2 (p = 0.sixty four). Median APACHE II scores had been comparable and period of cardiovascular aid wasn't substantially distinctive in between the 2 teams. Length of ICU continue to be (median [interquartile PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/21046519 range]) was longer in team 2 at six days [3-12] as opposed to 3 [1-7] (p < 0.001) however this significance was lost when non-survivors were excluded. There was a significantly lower requirement for RRT amongst ICU survivors in group 2 at 15.7 compared to 34 (p = 0.0078). Conclusions: We have shown a significant improvement in rate of RRT associated with implementation of our sepsis resuscitation bundle. Whilst implementation of care bundles has been associated with improved patient outcome, the basis of this relationship remains unclear [2]. Our work fails to demonstrate a significant reduction in mortality however we acknowledge the limitations of a small sample size. Median bundle compliance is higher than in other published work [2] however ongoing quality improvement work may increase this further. We identified a longer length of stay in group 2. This may represent either a longer period of treatment before deciding to change the focus of care to palliation or a faster decline in patients within group 1.References 1. Dellinger et al.: Crit Care Med 2004; 32: 858-73 2. Levy et al.: Intensive Care Med 2010; 36: 222-P048 Dose of norepinephrine in the first 24 hours as a parameter evaluating the effectiveness of treatment in patients with severe sepsis and septic shock P. Szturz 1, P. Folwarzcny1, J. Svancara2, R. Kula1, P. Sevcik1 1 University Hospital and Faculty of Medicine Ostrava University, Ostrava, Czech Republic; 2Institute of Biostatistics and analyses, Masaryk University, Brno, Czech Republic Critical Care 2016, 20(Suppl 2):P048 Introduction: Vasopressor therapy is required to sustain life and maintain perfusion in the face of life-threatening hypotension occurring with severe sepsis and septic shock, even when hypovolemia has not yet been resolved. [1] We hypothesized that a dose of norepinephrine administered in the first 24 hours correlates with the outcome of treatment in patients with PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/18111632 severe sepsis and septic shock. Methods: We analysed a complete of 632 consecutive clients with septic shock (sepsis-induced hypotension persisting regardless of sufficient fluid resuscitation) within the EPOSS databases (Data-based Evaluation and Prediction of Result in Severe Sepsis), which was created to watch and assess the therapy efficacy in individuals with extreme sepsis and septic shock. People were being admitted to taking part intense treatment models (twelve hospitals ?seventeen high-volume care models) while in the Czech Republic from 1st of January 2011 to fifth of November 2013. The clients were being divided into two teams: survivors (n = 316) and nonsurvivors (n = 316). Success: The groups of survivors vs. nonsurvivors ended up identical in: age sixty six.0 (39.0; eighty four.0) vs. sixty eight.0 (34.0;86.0) p = 0.162, adult males 184 (fifty eight.2 ) vs. one hundred ninety (60.1 ) p = 0.343, APACHE II rating 26.0 (fourteen.0; 39.0) vs. 28.0 (fourteen.0; forty.0) p = 0.565 as well as the Letrozole Couch score 10.0 (4.0 ?16.0) vs. ten.0 (3.0 ?16.0) p = 0.912. Administration on the dose of thirty mL/kg of crystalloids for hypotension or lactate four mmol/L (3 hours) and software of vasopressors (6 hours) was done in both equally groups, without having statistically considerable discrepancies. Statistically substantial discrepancies involving survivors vs. nonsurvivors were found during the parameter "Dose of norepinephrine inside the very first 24 hours", 0.211 (0.022 - 1.104).